The blue Ford sedan was reported stolen from a Port Augusta home on Friday afternoon, and was seen driving off from a petrol station in the same town about 10.30am yesterday.
The car was then seen several times in Whyalla, about 75 kilometres south of Port Augusta, and a police helicopter began to track its movements about 1.30pm.
It was seen travelling on Iron Knob Road, before heading west onto the Eyre Highway towards Kimba.
Police said the car hit speeds about 180km/h and was at times driving on the wrong side of the road.
The car briefly stopped at a rest stop about 2.40pm, allowing police to lay down road spikes.
The Ford hit the spikes and continued driving for about two kilometres before crashing.
The driver, a 33-year-old Hilton man, was found unconscious, with police attempting to revive him.
However, he was pronounced dead at the scene.
The death will be investigated as a death in custody, as the man was evading police at the time of the crash.
Police claim the decision to use road spikes was done to protect the safety of other drivers.
Major crash investigators initially attended the scene yesterday, and returned this morning to complete their investigation.
A report will be prepared for the coroner.
