Shoppers were seen scrambling through Pacific Werribee Shopping Centre in Hoppers Crossing after a major brawl unfolded about 4.30pm.
Vision shows a stampede of more than 50 youths surrounding a group of females who were throwing punches and kicks at other girls on the ground.
Students from multiple schools were involved in the fight, which unfolded in front of terrified shoppers doing last-minute Easter shopping.
Shoppers ran into nearby shops and huddled in store rooms during the lockdown, witnesses told 9News.
Police stepped in and used capsicum spray to disperse the crowd, at which point the students all run from the scene.
No arrests have been made and no injuries have been reported, police said.
The centre has since reopened, but there remains a significant police presence.
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