Police were called to the Murchison Highway between Rosebery and Zeehan at about 4.30pm after a crash between a red Honda ATV quad bike and a white Mitsubishi Triton.
Both people on the quad bike, a teenage girl from interstate and a 38-year-old man from Rosebery, died at the scene, despite assistance from interstate tourists.
The 40-year-old man who was driving the ute was uninjured and will be subject to mandatory drug and alcohol testing.
A report will be prepared for the coroner.
